Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

AbstractObjective: Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a high-pressure chamber. HBOT is a well established treatment for several diseases, such as serious infections, chronic diabetic foot ulcer, radiation injury, and hidradenitissuppurativa. There are various troublesome diseases that decrease pleasure in life in patients. HBOT has excellent effects in improv ing QOL in patients with acute and chronic diseases. The present study aimed at assessing the researches that focus on improvingthe QOL after HBO treatments.Methods: A systematic quest was conducted to evaluate English papers (clinical trials) that were published before April 2017. Wesearched PubMed, institute of scientific information (ISI), SCOPUS, Web of Science, Ovid, Science direct, ProQuest, Wiley, Cochran,Ebsco host, and Google Scholar. The reference lists of all the articles and electronic journals were searched for further studies. TheJAMA users guide evaluation scales for RCTs was used to assess quality of the researched articles. Inclusion and exclusion criteriawere extracted according to the scientific criteria. Sample size was 806 patients.Results: Finally, 15 published articles were extracted. Most researches were done in UK (26.7%), Israel (20%), and Sweden (20%). Themean age in HBOT group was 41.88, with a male to female ratio of 1.52. The mean age in the control group was 38.29, with a maleto female ratio of 2.14. The most frequent clinical trials were those on the treatment of diabetic foot ulcer (20%), post-concussionsyndrome (13.3%), pelvic radiotherapy (13.3%), and chronic arm lymphedema after radiotherapy (13.3%). The most QOL questionnairesused were SF-36 (21.4%), EORTC (European organization for research and treatment of cancer) QLQ-C30, head and neck cancer module(H&N35), and performance status scale (PSS).Conclusions: A significant effect of HBOT on improving QOL in patients’ outcomes and symptoms was found compared with thecontrol group. We found improved QOL in patients with diabetic foot ulcer, post-concussion syndrome, pelvic radiotherapy, poststroke, hidradenitis suppurativa, tonsillar fossa tumor radiotherapy, jaw osteonecrosis, and fibromyalgia syndrome. We suggestthat HBOT be added to conventional treatment of these patients as an adjuvant.

Categories: Medical clinic, Oncology, Wounds