Hyperbaric oxygen therapy for late radiation-induced tissue toxicity: prospectively patient-reported outcome measures in breast cancer patients

Introduction: This study examines patient reported outcome measures of women undergoing hyperbaric oxygentreatment (HBOT) after breast-conserving therapy.Method: Included were 57 women treated with HBOT for late radiation-induced tissue toxicity (LRITT) referred inthe period January 2014-December 2015. HBOT consisted of (on average) 47 sessions. In total, 80 min of 100 % O2was administered under increased pressure of 2.4 ATA. Quality of life was assessed before and after treatment usingthe European Organization for Research and Treatment of Cancer (EORTC) QLQ-BR23, and a NRS pain score.Results: Fifty-seven women were available for evaluation before and after treatment. Before HBOT, patients had severecomplaints of pain in the arm/shoulder (46 %), swollen arm/hand (14 %), difficulty to raise arm or move it sideways(45 %), pain in the area of the affected breast (67 %), swollen area of the affected breast (45 %), oversensitivity of theaffected breast (54 %), and skin problems on/in the area of the affected breast (32 %); post HBOT, severe complaintswere still experienced in 17, 7, 22, 15, 13, 15, and 11 % of the women, respectively. Differences were all significant.The NRS pain score improved at least 1 point (range 0–10) in 81 % of the patients (p < 0.05).Conclusion: In these breast cancer patients treated with HBOT for LRITT, the patient-reported outcomes werepositive and improvements were observed. HBOT was a well-tolerated treatment for LRITT and its side-effectswere both minimal and reversible.