Document Category: Child neurology

Hyperbaric oxygen preconditioning: a reliable option for neuroprotection

Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign …

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Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism

Abstract: Objective: To investigate the mechanism underlying the effect of hyperbaric oxygen (HBO) on hypoxic / ischemic brain damage (HIBD) in a neonatal rat model. Methods: A total of 30 neonatal SD rats aged 7 days were randomly assigned into control group, HIBD group and HBO group (n=10 per group). Following HIBD modeling in neonatal …

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Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

AbstractAutism spectrum disorder (ASD) afects~2% of children in the United States. The etiology of ASD likely involves environ mental factors triggering physiological abnormalities in genetically sensitive individuals. One of these major physiological  abnormalities is mitochondrial dysfunction, which may afect a signifcant subset of children with ASD. Here we systemati cally review the literature on human …

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Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, featuresof mitochondrial dysfunction in the general population of children with ASD were identified.Second, characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two …

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Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial

AbstractBackground: Several uncontrolled studies of hyperbaric treatment in children with autism have reported clinical improvements; however, this treatment has not been evaluated to date with acontrolled study. We performed a multicenter, randomized, double-blind, controlled trial to assess the efficacy of hyperbaric treatment in children with autism.Methods: 62 children with autism recruited from 6 centers, ages …

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Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions

Abstract: In hyperbaric oxygen therapy (HBOT), the subject is placed in a chamber containing 100%oxygen gas at a pressure of more than one atmosphere absolute. This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. In this review, we discuss the …

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Hyperbaric oxygen therapy is safe and effective for the treatment of sleep disorders in children with cerebral palsy

ABSTRACTObjective: To observe the effects of hyperbaric oxygen (HBO2) therapy on the treatment of sleep disorders and its safety in children with cerebral palsy (CP).Methods: A total of 71 recruited children were divided into two groups based on age: group 1, aged between 2 and 4 years; and group 2, aged between 4 and 6 years. The …

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Intensive rehabilitation combined with HBO2 therapy in children with cerebral palsy: A controlled longitudinal study

Objective: The present study aimed to assess the effect of intensive rehabilitation combined with hyperbaric oxygen (HBO2) therapy on gross motor function in children with cerebral palsy (CP).Methods: We carried out an open, observational, platform-independent study in 150 children with cerebral palsy with follow-up over eight months to compare the effects of standard intensive rehabili …

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Hyperbaric Oxygenation Therapy in the Treatment of Cerebral Palsy: A Review and Comparison to Currently Accepted Therapies

ABSTRACTHyperbaric oxygenation therapy (HBOT) has shown promise inclinical trials and is sought by many parents of children withcerebral palsy (CP). There is unusual resistance to expanding theindications for this modality, which is the only treatment available forcertain conditions, such as decompression sickness and airembolism, and which is effective in a number of others related towound …

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