Document Category: Infectology

Early hyperbaric oxygen therapy improves survival in a model of severe sepsi

Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH,Bickler SW, Perdrizet GA, De Maio A. Early hyperbaric oxygentherapy improves survival in a model of severe sepsis. Am J PhysiolRegul Integr Comp Physiol 317: R160 –R168, 2019. First publishedMay 15, 2019; doi:10.1152/ajpregu.00083.2019.—Sepsis is a majorclinical challenge, with therapy limited to supportive interventions. There fore, the …

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Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy

We present a case of rhino-orbitary mucormycosis which progressed despite liposomal amphotericin and early surgical debridement. Combined echinocandin and high dose liposomal amphotericin, repeated debridement, prolonged therapy with hyperbaric oxygen and continued therapy with posaconazole, along with strict diabetic control, allowed cure without disfigurement.

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Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample

Abstract Purpose: Necrotising soft tissue infection (NSTI) is a deadly disease associated with a sig nificant risk of mortality and long term disability from limb and tissue loss. The aim of this study was to determine the effect of hyperbaric oxygen (HBO2) therapy on mortality, complication rate, discharge status/ location, hospital length of stay and …

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Necrotising soft tissue infections: the effect of hyperbaric oxygen on mortality

SummaryIn a single-centre, retrospective, case-controlled study of patients attending the Alfred Hospital in Prahran, Victoria, we assessed the effect of hyperbaric oxygen therapy (HBOT) in reducing mortality or morbidity in patients with necrotising fasciitis (NF) over a 13-year period from 2002 to 2014. A total of three hundred and forty-one patients with NF were included in …

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Not Just Full of Hot Air: Hyperbaric Oxygen Therapy Increases Survival in Cases of Necrotizing Soft Tissue Infections

AbstractBackground: The utility of hyperbaric oxygen therapy (HBOT) in the treatment of necrotizing soft tissue in fections (NSTIs) has not been proved. Previous studies have been subject to substantial selection bias becauseHBOT is not available universally at all medical centers, and there is often considerable delay associated with itsinitiation. We examined the utility of HBOT …

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Hyperbaric oxygen therapy as an adjuvant to source control in necrotizing soft tissue infections

Introduction: Necrotizing soft tissue infections (NSTI) are rare but potentially lethal disorders, and adequate management is time- and resource-demanding. This study aims to assess whether variations in the treatment modalities – surgery, hyper baric oxygen (HBO2)therapy and negative pressure wound therapy – had an impact on the length to definitive source control in NSTI patients …

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Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis

Object. Hyperbaric oxygen therapy (HBO) is used as primary and/or adjunctive therapy in the treatment of vari ous clinical conditions complicated by local hypoxia. It may have therapeutic potential in the treatment of neurosur gical infections such as spinal osteomyelitis that are associated with significant morbidity rates. The purpose of this study was to evaluate …

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Could Hyperbaric Oxygen Be a Solution in the Treatment of Spinal Infections?

Abstract: Background and Objective: Pyogenic spinal infections are rare and potentially devastating, requiring prompt recognition and management. Parallel to the ever-increasing number of invasivespinal procedures, its incidence is on a steady rise, particularly in an expanding elderly population.The aim of this study was to evaluate the efficacy of hyperbaric oxygen (HBO2) therapy in the treatment …

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Transcutaneous Oxygen Measurements Under Hyperbaric Oxygen Conditions as a Predictor for Healing of Problem Wounds

Controversy exists as to what transcutaneous oxygen(PICO.) levels are required for wound healing and what role hyperbaric oxygen has for this. Current information suggests that 30 to 40 mmHg juxta-wound oxygen tensions in room air are required. We recorded P,cO. measurements in room air and with hyperbaric oxygen in 190 patients with foot wounds; then …

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Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: A Health Technology Assessment

ABSTRACTBackgroundAbout 15% to 25% of people with diabetes will develop a foot ulcer. These wounds are often resistant to healing; therefore, people with diabetes experience lower limb amputation at about 20 times the rate of people without diabetes. If an ulcer does not heal with standard wound care, other therapeutic interventions are offered, one of …

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