Document Category: Infectology

Infectious diseases: pathophysiology and mechanisms of hyperbaric oxygen

Hyperbaric oxygen (HBO) therapy has proved adjunctive along with antibiotics and surgery for the treatment of necrotizing soft tissue infections, refractory osteomyelitis, and infected ischemic wounds. The pathophysiology and mechanisms of HBO therapy explain these beneficial effects. Hyperbaric oxygen has a direct bactericidal effect on anaerobic organisms through the production of toxic oxygen radicals. Hyperbaric …

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Systematic review of the effectiveness of hyperbaric oxygenation therapy in the management of chronic diabetic foot ulcers

OBJECTIVE: To assess the efficacy and safety of hyperbaric oxygenation (HBO) therapy as adjunctive treatment for diabetic foot ulcers with a systematic review and meta-analysis of the literature. METHODS: MEDLINE, EMBASE, and the Cochrane Library were searched to find relevant articles published up to April 20, 2012, without restriction as to language or publication status. All controlled trials that evaluated adjunctive treatment with …

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Results of chronic osteomyelitis of the femur treated with hyperbaric oxygen: a preliminary report

Abstract BACKGROUND: Although only a few studies have shown the effectiveness, hyperbaric oxygen (HBO) therapy has been used as an adjunct in the management of chronic osteomyelitis in many hospitals in Taiwan. This retrospective study investigated the clinical results of HBO therapy for chronic refractory osteomyelitis of the femur. METHODS: From December 1999 through May 2002, 13 patients with chronic refractory osteomyelitis of the femur were treated with adjunctive HBO. The most common infecting microorganism was …

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Hyperbaric oxygen therapy augments tobramycin efficacy in experimental Staphylococcus aureus endocarditis

Abstract Staphylococcus aureus infective endocarditis (IE) is a serious disease with an in-hospital mortality of up to 40%. Improvements in the effects of antibiotics and host responses could potentially benefit outcomes. Hyperbaric oxygen therapy (HBOT) represents an adjunctive therapeutic option. In this study, the efficacy of HBOT in combination with tobramycin in S. aureus IE was evaluated. A rat model of S. aureus IE mimicking the bacterial load in humans …

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Efficacy of hyperbaric oxygen therapy in bacterial biofilm eradication

Abstract OBJECTIVE: Chronic wounds typically require several concurrent therapies, such as debridement, pressure offloading, and systemic and/or topical antibiotics. The aim of this study was to examine the efficacy of hyperbaric oxygen therapy (HBOT) towards reducing or eliminating bacterial biofilms in vitro and in vivo. METHOD: Efficacy was determined using in vitro grown biofilms subjected directly to HBOT for 30, 60 and 90 minutes, …

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