Document Category: Medical clinic

Impact of hyperbaric oxygenation on oxidative stress in diabetic patients

Taking into consideration that high concentration of oxygencan express toxic effects due to production of reactive oxygenspecies (ROS), the aim of our investigation was to establishthe influence of hyperbaric oxygenation on oxidative stressparameters and antioxidant enzymes in patients with diabetesmellitus (DM) type 2. Investigation included 50 patients withDM type 2 divided into two groups. The …

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Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy

Background: Our previous study suggested that HBO treatment attenuated neuropathic pain by inhibiting mTOR to induce autophagy in SNL neuropathic pain model. The aim of this study was to evaluate the role of AKT/TSC2/mTOR pathway in SNL and autophagy and determine whetherHBO treatment could relieve neuropathic pain via modulating AKT/TSC2/mTOR pathway. Materials and methods: Rats …

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Effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia

Purpose: Hyperbaric oxygen (HBO) therapy has been suggested to palliate neuropathic pain, but the mechanisms involvedare not well understood. This study explored the involvement of microglial mitophagy via HBO relative to neuropathic paintherapy.Materials and methods: A total of 80 male Sprague Dawley rats were randomly divided into two groups: a normal group(n 1⁄4 40) and …

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Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia by upregulation of antioxidant enzymes in rabbits

The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham …

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The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

The effects of hyperbaric oxygen (HBO) therapy on oxidant/antioxidant metabolism are controversial and its effects on hepatic regeneration are not known. In this study, we investigated a possible beneficial effect of HBO therapy on oxidant and antioxidants levels during liver regeneration. To conduct this study, seventy percent hepatectomy was performed on forty-eight Spraggue Dawley rats …

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Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-kB Signaling Pathway

Background: The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. Material/Methods: A rat model of TBI was constructed using the modified Feeney’s free-fall method, and 60 SD rats were random-ly divided into three groups – the sham group, …

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Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-κ B-Mediated Signaling Pathway

Background/Aims: Previous studies have proved that the activation of TLR4/NF-κ B signaling pathway is involved in inflammatory processes in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Hyperbaric oxygen (HBO) intervention has successfully been used to treat several animal models of tissue injury via its anti-inflammation property. This study was undertaken to investigate the influence …

Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-κ B-Mediated Signaling Pathway Read More »

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Hyperbaric Oxygen Inhibits Ischemia-Reperfusion Induced Neutrophil CD18 Polarization by a Nitric Oxide Mechanism

Background—Hyperbaric oxygen (HBO) decreases ischemia-reperfusion (IR) induced neutrophil-ICAM adhesion by blocking CD18 polarization. The purpose of this study was to evaluate whether this HBO effect is nitric oxide (NO) dependent and to determine if NO synthase (NOS) is required. Methods—A gracilis muscle flap was raised in 9 groups of male Wistar rats. Global ischemic injury …

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An overview of protective strategies against ischemia/reperfusion injury: The role of hyperbaric oxygen preconditioning

Introduction: Ischemia/reperfusion (I/R) injury, such as myocardial infarction, stroke, and peripheral vascular disease, has been recognized as the most frequent causes of devastating disorders and death currently. Protective effect of various preconditioning stimuli, including hyperbaric oxygen (HBO), has been proposed in the management of I/R. Methods: In this study, we searched and reviewed up-to-date published …

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Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model

Abstract: Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation inrats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effectsof HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley(SD) rats were randomly assigned to the following six groups (n = 6 per group): (1) sham burnwith sham HBO treatment; …

Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model Read More »

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