Document Category: Medical clinic

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

AbstractBackground: Hyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during astrocyte activation and inflammation in a rodent model of neuropathic pain.Methods: Rats were assigned into sham operation, chronic constriction injury (CCI), and CCI + …

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Effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia

AbstractPurpose: Hyperbaric oxygen (HBO) therapy has been suggested to palliate neuropathic pain, but the mechanisms involvedare not well understood. This study explored the involvement of microglial mitophagy via HBO relative to neuropathic paintherapy.Materials and methods: A total of 80 male Sprague Dawley rats were randomly divided into two groups: a normal group(n ¼ 40) and …

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Hyperbaric Oxygen Treatment at Various Stages following Chronic Constriction Injury Produces Different Antinociceptive Effects via Regulation of P2X4R Expression and Apoptosis

PurposeThe aims of this study were to investigate the effect of hyperbaric oxygen (HBO) treatment at various stages following chronic constriction injury (CCI) and to explore the underlyingmechanisms of HBO treatment.MethodsForty adult male Sprague—Dawley rats were randomly assigned to five groups (n = 8 for each group): the sham group, CCI group, HBO1 group, HBO2 …

Hyperbaric Oxygen Treatment at Various Stages following Chronic Constriction Injury Produces Different Antinociceptive Effects via Regulation of P2X4R Expression and Apoptosis Read More »

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A Prolonged NO-Dependent, Opioid-Mediated Antinociceptive Effect of Hyperbaric Oxygen in Mice

AbstractHyperbaric oxygen (HBO2) therapy is reported to cause pain relief in several conditions of chronicpain. A single 60-min session of HBO2 treatment produced a prolonged antinociceptive effect inmice that persisted for 90 min after cessation of treatment. The HBO2-induced antinociception wassignificantly attenuated by pretreatment prior to HBO2 exposure with the opioid antagonistnaltrexone, the non-specific nitric …

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Protocols for the use of a portable hyperbaric chamber for the treatment of high altitude disorders

Descent remains the definitive treatment for high altitude illness. However, in alpine settings of over 8000 ft, immediate evacuation is often impossible. A portable, lightweight (7 kg) hyperbaric bag has been devised capable of withstanding a pressure of 2 psi. The author investigated the optimal period of treatment in the bag to achieve resolution of …

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Treatment of moderate acute mountain sickness with pressurization in a portable hyperbaric (Gamow™) Bag

The Gamow Bag™ has recently been introduced as a treatment modality for acute mountain sick ness (AMS), but clinical experience with its use is limited. We report our use of this modality duringone season at the Himalayan Rescue Association Aid Post in Manang, Nepal (altitude 3550 m).Ten subjects with symptoms of moderate AMS were offered …

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Using a new plateau hyperbaric chamber to alleviate high altitude hypoxia: Rabbit and human studies

Objectives: To validate the effects of the new plateau hyperbaric chamber on alleviating high altitude hypoxia onMount Kun Lun.Methods: A prospective, controlled study of rabbits and adult volunteers was conducted at altitudes of 355, 2880 and4532 m. We obtained arterial blood samples from rabbits and volunteers before and after hyperbaric treatment. The respiratory rate, heart …

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Simulated descent v dexamethasone in treatment ofacute mountain sickness: a randomised trial

AbstractObjective-Evaluation and comparison of the therapeutic efficacy of a portable hyperbaric chamber and dexamethasone in the treatment of acute mountain sickness.Design-Randomised trial during the summer mountaineering season.Setting-High altitude research laboratory in the Capanna Regina Margherita at 4559m above sea level (Alps Valais).Subjects-31 climbers with symptoms of acute mountain sickness randomly assigned to different treatments.Interventions-One hour …

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Treatment of Acute Mountain Sickness: Hyperbaric Versus Oxygen Therapy

Study objectives: To compare the benefits of simulated descent in a hy perbaric chamber with those of supplementary oxygen for the treatment of acute mountain sickness. Design: A prospective study. Setting: The Snake River Health Clinic in Keystone, Colorado, which has an altitude of 2,850 m (9,300 it). Type of participants: Twenty-four patients who presented with acute …

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Treatment of acute mountain sickness by simulated descent: a randomised controlled trial

AbstractObjective-To evaluate the therapeutic efficacy of a portable hyperbaric chamber for treatment of acute mountain sickness.Design-Controlied randomised trial over two mountaineering seasons.Setting-High altitude research laboratory at 4559 m above sea level.Subjects-64 climbers with acute mountain sick ness randomly allocated to different treatments.Interventions-One hour oftreatment in the hyper baric chamber at a pressure of 193 mbar …

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