Background: Vascular dementia (VD) is a common type of disease in the elderly. Numerous clinical trials have suggested that hyperbaric oxygen is an effective and safe complementary therapy for aging-related disorders. However, there is no reliable systematic evidence regarding hyperbaric oxygen therapy (HBOT) for the treatment of VD. Therefore, we performed a meta-analysis to evaluate the …
A 58-year-old female was diagnosed with Alzheimer’s dementia (AD) which was rapidly progressive in the 8 months prior to initiation of hyperbaric oxygen therapy (HBOT). 18Fluorodeoxyglucose (18FDG) positron emission tomography (PET) brain imaging demonstrated global and typical metabolic deficits in AD (posterior temporal-parietal watershed and cingulate areas). An 8-week course of HBOT re versed the patient’s …
AbstractRationale: Patients with Parkinson’s disease (PD) frequently suffer from psychiatric disorders, and treating these symptom whereas managing the motor symptoms associated with PD can be a therapeutic challenge.Patient concerns: We report a case of PD patient with severe depression and anxiety that refused to be treated withdopaminagonists or SSRIs, the most common treatments for PD …
Hyperbaric oxygen treatment for Parkinson’s disease with severe depression and anxiety Read More »
Purpose: To investigate the effects of hyperbaric oxygen (HBO) pretreatment on cognitive decline and neuronal damage in an Al zheimer’s disease (AD) rat model.Materials and Methods: Rats were divided into three groups: normal saline (NS), AD, and HBO+AD. In the AD group, amyloid βpeptide (Aβ)1-40 was injected into the hippocampal CA1 region of the brain. …
We examined whether exposure to mild hyperbaric oxygen inhibits the decrease of dopaminergic neu rons in the substantia nigra of a neurotoxic animal model with Parkinson’s disease. Mice injected with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride and probenecid twice a week were divided into two groups: mice with mild hyperbaric oxygen and those without. The mice with mild hyperbaric oxygen …
Parkinson’s disease (PD) is a common movement disorder in the elderly. In the present study, weexamined whether the combination of hyperbaric oxygen (HBO) and madopar therapy provided a neu roprotective effect on dopaminergic neurons in the substantia nigra using a rat model of PD. Rotational assessments revealed that both HBO and combination therapy significantly attenuated …
Hyperbaric oxygen (HBO) therapy has been used in a number of conditions characterized by global ischemia (as opposed to focal ischemia of stroke), and anoxia, and leading to impairment of consciousness. Conditions such as coma due to brain injury and anoxia asso ciated with drowning and hanging are discussed under the following headings: (1) patho …
HBO Therapy in Global Cerebral Ischemia/Anoxia and Coma Read More »
The effectiveness and efficacy of hyperbaric oxygen (HBO) preconditioning and post-treatment modalities have been demonstrated in experimental models of ischemic cerebrovascular diseases, including global brain ischemia, transient focal and permanent focal cerebral ischemia, and experimental neonatal hypoxia-ischemia encephalopathy. In general, early and repetitive post-treatment of HBO appears to create enhanced protection against brain ischemia whereas …
Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign …
Hyperbaric oxygen preconditioning: a reliable option for neuroprotection Read More »
Abstract: Objective: To investigate the mechanism underlying the effect of hyperbaric oxygen (HBO) on hypoxic / ischemic brain damage (HIBD) in a neonatal rat model. Methods: A total of 30 neonatal SD rats aged 7 days were randomly assigned into control group, HIBD group and HBO group (n=10 per group). Following HIBD modeling in neonatal …
