Document Category: Medical clinic

Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen

Background: Carbon monoxide (CO) poisoning is the leading cause of poisoning mortality and morbidity in the USA. Carboxyhemoglobin (COHb) levels are not predictive of severity or prognosis. At this time, the measurement of mitochondrialrespiration may serve as a biomarker in CO poisoning. The primary objective of this study was to assess changes in mitochondrial function …

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Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy

Carbon monoxide (CO) poisoning affects 50,000 people a year in theUnited States. The clinical presentation runs a spectrum, ranging fromheadache and dizziness to coma and death, with a mortality rate rangingfrom 1 to 3%. A significant number of patients who survive COpoisoning sufferfrom long-term neurological and affective sequelae. Theneurologic deficits do not necessarily correlate with …

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Mitochondrial Injury in Human Acute Carbon Monoxide Poisoning: The Effect of Oxygen Treatment

The best oxygen therapy for acute carbon monoxide poisoning (ACOP) remains un established. Reported mitochondrial complex IV (mtCIV) inhibition, together with car boxyhaemoglobin (COHb)-induced hypoxia, may influence acute clinical symptoms andoutcome. To “mitochondrially” evaluate treatment efficacy, we correlated intoxication severity and symptoms with mitochondrial function (mtCIV activity) and oxidative stress (lipid peroxidation) in 60 poisoned …

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Hyperbaric oxygen therapy may be effective to improve hypoxemia in patients with severe COVID-2019 pneumonia: two case reports

Objective: To determine whether hyperbaric oxygen (HBO2) therapy be effective to improve hypoxemia for severe COVID-19 pneumonia patients. Method: Two male patients ages 57 and 64 years old were treated. Each met at least one of the following criteria: shortness of breath; respiratory rate (RR) ≥30 breaths/minute; finger pulse oxygen saturation (SpO2) ≤93% at rest; …

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The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review

The recent coronavirus disease 2019 (COVID-19) pandemic produced high and excessivedemands for hospitalizations and equipmentwith depletion of critical care resources. Theresults of these extreme therapeutic effortshave been sobering. Further, we are monthsaway from a robust vaccination effort, andcurrent therapies provide limited clinical relief.Therefore, several empirical oxygenation supportinitiatives have been initiated with intermittenthyperbaric oxygen (HBO) therapy …

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Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accidents

AbstractBackground: Hydrogen cyanide (HCN) and carbon monoxide (CO) may be important components of smoke from fire accidents. Accordingly, patients admitted to hospital from fire accidents may have been exposed to both HCN and CO. Cyanide (CN) intoxication results in cytotoxic hypoxia leading to organ dysfunction and possibly death. While several reports support the use of hyperbaric …

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Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial

AbstractBackground: Recovery after stroke correlates with non-active (stunned) brain regions, which may persist for years. Thecurrent study aimed to evaluate whether increasing the level of dissolved oxygen by Hyperbaric Oxygen Therapy (HBOT)could activate neuroplasticity in patients with chronic neurologic deficiencies due to stroke.Methods and Findings: A prospective, randomized, controlled trial including 74 patients (15 were …

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Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns

A significant and consistently positive body of evi dence from animal and human studies of thermal injury support the use of hyperbaric oxygen as a means of preventing dermal ischemia, reducing edema, modulating the zone of stasis, preventing partial- to full-thickness conversion, preserving cel lular metabolism and promoting of healing. The vast majority of clinical …

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Hyperbaric Oxygen and Ginkgo Biloba Extract Ameliorate Cognitive and Memory Impairment via Nuclear Factor Kappa‑B Pathway in Rat Model of Alzheimer’s Disease

Background: Hyperbaric oxygen (HBO) and Ginkgo biloba extract (e.g., EGB 761) were shown to ameliorate cognitive and memory impairment in Alzheimer’s disease (AD). However, the exact mechanism remains elusive. The aim of the present study was to investigate the possible mechanisms of HBO and EGB 761 via the function of nuclear factor kappa‑B (NF‑κB) pathway.Methods: AD …

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Hyperbaric oxygen therapy for chronic wounds

BACKGROUND: Chronic wounds are common and present a health problem with significant effect on quality of life. Various pathologies may cause tissue breakdown, including poor blood supply resulting in inadequate oxygenation of the wound bed. Hyperbaric oxygen therapy (HBOT) has been suggested to improve oxygen supply to wounds and therefore improve their healing. OBJECTIVES: To assess the benefits and harms of adjunctive HBOT for treating chronic ulcers …

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