Document Category: Neurology

Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial

BackgroundFibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impairthe quality of life of 2–4% of the population, with 9:1 female-to-male incidence ratio. FMS isan important representative example of central nervous system sensitization and is associ ated with abnormal brain activity. Key symptoms include chronic widespread pain, allodyniaand diffuse tenderness, along with fatigue …

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Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients

Background: Neuropathic pain after nerve injury is severe and intrac table, and current drug and non-drug therapies offer very limited pain relief.Hyperbaric oxygen (HBO2) has been clinically used for protection of thenervous system after acute injury. We investigated whether HBO2 treatmentcould prevent and/or attenuate neuropathic pain in animals and in patients.Methods: Mechanical allodynia and thermal …

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Effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia

AbstractPurpose: Hyperbaric oxygen (HBO) therapy has been suggested to palliate neuropathic pain, but the mechanisms involvedare not well understood. This study explored the involvement of microglial mitophagy via HBO relative to neuropathic paintherapy.Materials and methods: A total of 80 male Sprague Dawley rats were randomly divided into two groups: a normal group(n ¼ 40) and …

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Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis

Object. Hyperbaric oxygen therapy (HBO) is used as primary and/or adjunctive therapy in the treatment of vari ous clinical conditions complicated by local hypoxia. It may have therapeutic potential in the treatment of neurosur gical infections such as spinal osteomyelitis that are associated with significant morbidity rates. The purpose of this study was to evaluate …

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Could Hyperbaric Oxygen Be a Solution in the Treatment of Spinal Infections?

Abstract: Background and Objective: Pyogenic spinal infections are rare and potentially devastating, requiring prompt recognition and management. Parallel to the ever-increasing number of invasivespinal procedures, its incidence is on a steady rise, particularly in an expanding elderly population.The aim of this study was to evaluate the efficacy of hyperbaric oxygen (HBO2) therapy in the treatment …

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Hyperbaric oxygen therapy of spinal cord injury

Spinal cord injury (SCI) is a complex disease process that involves both primary and secondary mechanisms of injury and can leave patients with devastating functional impairment as well as psychological debilitation. While no curative treatment is available for spinal cord injury, current therapeutic approaches focus on reducing the secondary injury that follows SCI. Hyperbaric oxygen (HBO) therapy has …

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Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury

Abstract. The inflammatory response is an important source of secondary damage to neuronal tissue in the spinal cord following spinal cord injury (SCI). Hyperbaric oxygen (HBO) therapy reduces inflammation and promotes the restoration of locomotor function following SCI, however, the mechanisms underlying this effect remain to be determined. The aim of the current study was to investigate the mechanisms by which HBO …

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Effect of mesenchymal stem cells transplantation combining with hyperbaric oxygen therapy on rehabilitation of rat spinal cord injury

Objective: To investigate the effect of BMSCs transplantation plus hyperbaric oxygen(HBO) on repair of rat SCI.Methods: Seventy five male rats were divided randomly into five groups: sham, vehicle,BMSCs transplantation group, combination group, 15 rats in each group. Every weekafter the SCI onset, all animals were evaluated for behavior outcome by Basso–Beattle–Bresnahan (BBB) score and inclined …

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