Document Category: Neurology

Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy

Background: Our previous study suggested that HBO treatment attenuated neuropathic pain by inhibiting mTOR to induce autophagy in SNL neuropathic pain model. The aim of this study was to evaluate the role of AKT/TSC2/mTOR pathway in SNL and autophagy and determine whetherHBO treatment could relieve neuropathic pain via modulating AKT/TSC2/mTOR pathway. Materials and methods: Rats …

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Effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia

Purpose: Hyperbaric oxygen (HBO) therapy has been suggested to palliate neuropathic pain, but the mechanisms involvedare not well understood. This study explored the involvement of microglial mitophagy via HBO relative to neuropathic paintherapy.Materials and methods: A total of 80 male Sprague Dawley rats were randomly divided into two groups: a normal group(n 1⁄4 40) and …

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Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia by upregulation of antioxidant enzymes in rabbits

The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham …

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Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-kB Signaling Pathway

Background: The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. Material/Methods: A rat model of TBI was constructed using the modified Feeney’s free-fall method, and 60 SD rats were random-ly divided into three groups – the sham group, …

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Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model

Abstract: Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation inrats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effectsof HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley(SD) rats were randomly assigned to the following six groups (n = 6 per group): (1) sham burnwith sham HBO treatment; …

Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model Leer más »

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Can hyperbaric oxygen be used to prevent deep infections in neuro-muscular scoliosis surgery?

AbstractBackground: The prevalence of postoperative wound infection in patients with neuromuscular scoliosis surgery is significantly higher than that in patients with other spinal surgery. Hyperbaric oxygen has been used as a supplement to treat postsurgical infections. Our aim was to determine beneficiary effects of hyperbaric oxygentreatment in terms of prevention of postoperative deep infection in …

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Evaluation of a Hyperbaric Oxygen Therapy Intervention in Individuals with Fibromyalgia

AbstractObjective. To evaluate the feasibility and safety of hyperbaric oxygen therapy (HBOT) in patients with fibromyalgia (FM). Design. A cohort study with a delayed treatment arm used as a comparator. Setting. Hyperbaric Medicine Unit, Toronto General Hospital, Ontario, Canada. Subjects. Eighteen patients diagnosed with FM according tothe American College of Rheumatology and a score 60 …

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Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial

AbstractBackground: Fibromyalgia (FM) is characterized by chronic pain and fatigue, among other manifestations, thus advising interventions that do not aggravate these symptoms. The main  purpose of this study is to analyse the effect of low-pressure hyperbaric oxygen therapy (HBOT) on induced fatigue, pain, endurance and functional capacity, physical performance and cortical excitability when compared with a physical …

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial Leer más »

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Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography

ABSTRACTObjective. Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxy gen through an oxygen mask. HBOT in FM induces changes in cortical excita bility and a secondary reduction in pain and muscle fatigue. However, there are still no direct data indicating changes in muscle fatigue. …

Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography Leer más »

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Hyperbaric oxygen treatment of fibromyalgia: a prospective observational clinical trial

ABSTRACTObjective. Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculo skeletal pain, fatigue and disordered sleep, and often associated with neu ropsychiatric and cognitive symptoms. Current treatment options are only par tially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of …

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