Document Category: Neurology

Hyperbaric oxygen for experimental intracerebral haemorrhage: Systematic review and stratified meta-analysis

ABSTRACTObjective: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However,HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinicalstudies. Therefore, we conducted this systematic review and meta-analysis on studies describing theefficacy of HBO in animal models of ICH.Methods: Studies were identified by searching mainstream databases through November 2015. …

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The National Brain Injury, Rescue and Rehabilitation Study – a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms

The National Brain Injury Rescue and Rehabilitation Project was established as a preliminary study to test the safety and practicality of multi-center hyperbaric oxygen administration for the post-concussive symptoms of chronic mild traumatic brain injury as a precursor to a pivotal, independent, multi-center, controlled clinical trial. This report presents the results for 32 subjects who …

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Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder

Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epi demic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. …

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Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside

Traumatic brain injury (TBI) is a serious public health problem in the United States. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities. So far there is no effective treatment/intervention in the daily clinical practice for TBI patients. The protective effects of hyperbaric oxygen therapy (HBOT) have been proved in stroke; however, its …

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Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial

AbstractBackground: Traumatic brain injury (TBI) is the leading cause of death and disability in the US. Approximately 70-90% of theTBI cases are classified as mild, and up to 25% of them will not recover and suffer chronic neurocognitive impairments. Themain pathology in these cases involves diffuse brain injuries, which are hard to detect by anatomical …

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A Phase I Study of Low-Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post-Concussion Syndrome and Post-Traumatic Stress Disorder

AbstractThis is a preliminary report on the safety and efficacy of 1.5 ATA hyperbaric oxygen therapy (HBOT) in militarysubjects with chronic blast-induced mild to moderate traumatic brain injury (TBI)/post-concussion syndrome(PCS) and post-traumatic stress disorder (PTSD). Sixteen military subjects received 40 1.5 ATA/60 min HBOTsessions in 30 days. Symptoms, physical and neurological exams, SPECT brain imaging, …

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Successful treatment of brain radiation necrosis resulting from triple-negative breast cancer with Endostar and short-term hyperbaric oxygen therapy: a case report

Abstract: Radiation necrosis (RN) is one of the complications of radiotherapy.Angiogenesis is a key factor underlying the development of RN, and Endostar, a safe and well-tolerated recombinant human endostatin, has been used to treat a variety of tumors.Thus far, however, no definitive reports on the use of Endostar for RN treatment have been reported. Here, …

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Successful treatment of radiation-induced brain necrosis by hyperbaric oxygen therapy

We describe a 68-year-old man who underwent hyperbaric oxygen (HBO) therapy to manage radiation necrosis of the brain, whichdeveloped after two treatments with stereotactic radiosurgery (SRS) to the same lesion. The necrosis was subsequently treated with steroids alone for 2 months; however, he progressed clinically and radiographically. Improvement again was noted with the reinstitution of …

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A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury

Object. Oxygen delivered in supraphysiological amounts is currently under investigation as a therapy for severe traumatic brain injury (TBI). Hyperoxia can be delivered to the brain under normobaric as well as hyperbaricconditions. In this study the authors directly compare hyperbaric oxygen (HBO2) and normobaric hyperoxia (NBH)treatment effects.Methods. Sixty-nine patients who had sustained severe TBIs (mean …

A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury Read More »

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How and why hyperbaric oxygen therapy can bring new hope for children suffering from cerebral palsy – An editorial perspective

Cerebral palsy (CP) is generally considered a non progressive condition resulting from neurological injury in the antenatal or perinatal period. The increased survival rates of premature infants due to advances in neonatal intensive care has led to increased incidence of CP, which is now higher than three in 1,000 births. Perinatal hypoxic-ischemic (HI) events resulting in …

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