Document Category: Oncology

Background: This study investigated the effects of hyperoxic treatment on growth,angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced ratmammary tumors.Methods: One group of animals was exposed to normobaric hyperoxia (1 bar, pO2 = 1.0 bar)and another group was exposed to hyperbaric hyperoxia (1.5 bar, pO2 = 1.5 bar). A third groupwas treated with the …

Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors Read More »

Abstract: Background. Hyperbaric oxygen (HBO2) is usedto promote healing in irradiated tissues, but concern persistsabout the possibility that it may promote residual tumor growth.Methods. The tumor growth of SQ20B and Detroit 562head and neck squamous cell carcinoma xenografts werestudied after single-dose irradiation and 5 /week HBO2 treat ment at 2.4 atm absolute for 90 minutes. …

EFFECTS OF HYPERBARIC OXYGEN EXPOSURE ON EXPERIMENTAL HEAD AND NECK TUMOR GROWTH, OXYGENATION, AND VASCULATURE Read More »

AbstractTumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as progenitors or cancer stem cells. Anti-angiogenic therapies using …

Tumor angiogenesis: causes, consequences, challenges and opportunities Read More »

Abstract Tumor blood vessels are a key target for cancertherapeutic management. Tumor cells secrete high levels ofpro-angiogenic factors which contribute to the creation ofan abnormal vascular network characterized by disorga nized, immature and permeable blood vessels, resulting inpoorly perfused tumors. The hypoxic microenvironmentcreated by impaired tumor perfusion can promote theselection of more invasive and aggressive …

Tumor angiogenesis and vascular normalization: alternative therapeutic targets Read More »

Abstract: As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrialdysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed …

The Significance of Mitochondrial Dysfunction in Cancer Read More »

Abstract: Hypoxia exists to some degree in most solid tumors due to inadequate oxygen delivery of the abnormal vasculature which cannot meet the demands of the rapidly proliferating cancer cells. The levels of oxygenation within the same tumor are highly variable from one area to another and can change over time. Tumor hypoxia is an …

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment Read More »

AbstractAging and cancer are the most important issues to research. The population in the world is growing older, and the incidence of cancer increases with age. There is no doubt about the linkage between aging and cancer. However, the molecular mechanisms underlying this association are still unknown. Several lines of evidence suggest that the oxidative stress …

Mitochondrial dysfunction and oxidative stress in aging and cancer Read More »

AbstractDeregulated cellular energetics was one of the cancer hallmarks. Several underlying mechanisms of deregulated cellular ener getics are associated with mitochondrial dysfunction caused by mitochondrial DNA mutations, mitochondrial enzyme defects, oraltered oncogenes/tumor suppressors. In this review, we summarize the current understanding about the role of mitochondrial dysfunction in cancer progression. Point mutations and copy number …

Role of mitochondrial dysfunction in cancer progression Read More »