Document Category: Pediatrics

Hyperbaric oxygen therapy for pediatric “hypospadias cripple”devaluating the advantages regarding graft take

SummaryIntroductionHypospadias cripple patients pose a major surgical chal lenge with high complication rates attributed mainly to graft contraction. Hyperbaric oxygen therapy (HBOT) is an established treatment for compromised grafts and used extensively as a salvage therapy for compromised grafts and ischemic non-healing wounds.ObjectiveWe evaluated the graft-take rates in hypospadias cripple cases undergoing a staged tubularized …

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Hyperbaric oxygen modalities are differentially effective in distinct brain ischemia models

The effectiveness and efficacy of hyperbaric oxygen (HBO) preconditioning and post-treatment modalities have been demonstrated in experimental models of ischemic cerebrovascular diseases, including global brain ischemia, transient focal and permanent focal cerebral ischemia, and experimental neonatal hypoxia-ischemia encephalopathy. In general, early and repetitive post-treatment of HBO appears to create enhanced protection against brain ischemia whereas …

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Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

AbstractAutism spectrum disorder (ASD) afects~2% of children in the United States. The etiology of ASD likely involves environ mental factors triggering physiological abnormalities in genetically sensitive individuals. One of these major physiological  abnormalities is mitochondrial dysfunction, which may afect a signifcant subset of children with ASD. Here we systemati cally review the literature on human …

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Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, featuresof mitochondrial dysfunction in the general population of children with ASD were identified.Second, characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two …

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Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial

AbstractBackground: Several uncontrolled studies of hyperbaric treatment in children with autism have reported clinical improvements; however, this treatment has not been evaluated to date with acontrolled study. We performed a multicenter, randomized, double-blind, controlled trial to assess the efficacy of hyperbaric treatment in children with autism.Methods: 62 children with autism recruited from 6 centers, ages …

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Hyperbaric oxygen therapy is safe and effective for the treatment of sleep disorders in children with cerebral palsy

ABSTRACTObjective: To observe the effects of hyperbaric oxygen (HBO2) therapy on the treatment of sleep disorders and its safety in children with cerebral palsy (CP).Methods: A total of 71 recruited children were divided into two groups based on age: group 1, aged between 2 and 4 years; and group 2, aged between 4 and 6 years. The …

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Intensive rehabilitation combined with HBO2 therapy in children with cerebral palsy: A controlled longitudinal study

Objective: The present study aimed to assess the effect of intensive rehabilitation combined with hyperbaric oxygen (HBO2) therapy on gross motor function in children with cerebral palsy (CP).Methods: We carried out an open, observational, platform-independent study in 150 children with cerebral palsy with follow-up over eight months to compare the effects of standard intensive rehabili …

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How and why hyperbaric oxygen therapy can bring new hope for children suffering from cerebral palsy – An editorial perspective

Cerebral palsy (CP) is generally considered a non progressive condition resulting from neurological injury in the antenatal or perinatal period. The increased survival rates of premature infants due to advances in neonatal intensive care has led to increased incidence of CP, which is now higher than three in 1,000 births. Perinatal hypoxic-ischemic (HI) events resulting in …

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Hyperbaric Oxygenation Therapy in the Treatment of Cerebral Palsy: A Review and Comparison to Currently Accepted Therapies

ABSTRACTHyperbaric oxygenation therapy (HBOT) has shown promise inclinical trials and is sought by many parents of children withcerebral palsy (CP). There is unusual resistance to expanding theindications for this modality, which is the only treatment available forcertain conditions, such as decompression sickness and airembolism, and which is effective in a number of others related towound …

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Hyperbaric oxygen treatment of superficial soft tissue lesions in children with oncologic disease

This study aimed to assess the feasibility and results of hyperbaric oxygen therapy (HOT) as supportive treatment of lesions of superficial soft tissues in children with oncological diseases. This was a retrospective analysis and review of all records of children observed at the Pediatric Hematology-Oncology Department of the University of Padova and treated adjuvantly with HOT. Between 1996 and 2010, 12 patients (5 males and 7 females, median age …

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