In this double-blind, randomized, placebo controlled study we aimed to assess the effectiveness of hyperbaric oxygen (HBO)therapy for treating patients with complex regional pain syndrome (CRPS). Of the 71 patients, 37 were allocated to the HBO group and 34 to the control (normal air) group. Both groups received 15 therapy sessions in a hyperbaric chamber. …
Study Design. An in vivo study was conducted to test the effect of hyperbaric oxygenation (HBO) on intervertebral disc degeneration in Sprague-Dawley rats. Objective. To observe the changes in intervertebral disc height and levels of glycosaminoglycan, collagen, interleukin-1 β (IL-1 β), prostaglandin E 2 (PGE 2 ), and inducible nitric oxide synthase (iNOS) in degenerated intervertebral discs after HBO therapy. Summary …
Effect of Hyperbaric Oxygenation on Intervertebral Disc Degeneration Read More »
ABSTRACTObjectives: We sought to investigate and prove the effect of hyperbaric oxygen therapy (HBOT) on T helper 17 (Th17)/regulatory T (Treg) cell polarization through changes in the expression of hypoxia-inducible factor-1 alpha (HIF-1α) in rheumatoid arthritis (RA) animal model. Methods: We used antigen and collagen-induced arthritis (ACIA) as a RA animal model. Sixteen male BALB/c models …
ABSTRACT: Heat shock proteins (HSPs), inflammatory cytokines, nitric oxide (NO), and localized hypoxia-induced apoptosis arethought to be correlated to the degree of cartilage injury. We investigated the effect of hyperbaric oxygen (HBO) on (1) interleukin-1b (IL-1b)-induced NO production and apoptosis of rabbit chondrocytes and (2) healing of articular cartilage defects. For the in vitro study, …
Abstract Proinflammatory cytokine, nitric oxide (NO) and localized hypoxia-induced apoptosis and proteoglycan (PG) degradation are thought to be correlated to the degree of cartilage injury. This study evaluated hyperbaric oxygen (HBO)-induced changes in joint cavity oxygen tension, antigenickeratan sulfate (KS) content, inducible nitric oxide synthase (iNOS) expression, PG synthesis, and cell apoptosis in full-thickness defects of rabbit …
AbstractThe effects of hyperbaric oxygen (HBO2) therapy on the immune system are reported including potential changes to the CD4/CD8 ratio anda decreased proliferation of lymphocytes during exposure. The immunosuppressive effect of HBO2 had been suggested to be applicable for thetreatment of certain autoimmune diseases. (NZB NZW) F1 hybrid mice, the unique lupus-prone mice, have been …
Background: Our previous study suggested that HBO treatment attenuated neuropathic pain by inhibiting mTOR to induce autophagy in SNL neuropathic pain model. The aim of this study was to evaluate the role of AKT/TSC2/mTOR pathway in SNL and autophagy and determine whether HBO treatment could relieve neuropathic pain via modulating AKT/TSC2/mTOR pathway.Materials and methods: Rats were randomly divided …
AbstractObjective: To observe the analgesic effect of early hyperbaric oxygen (HBO) treatment in chronic constriction injury (CCI)rats, and to analyze the influence of HBO on the expression of neuronal nitric oxide synthase and inducible nitric oxidesynthase and on the levels of inflammatory factors.Methods: Rats were assigned into three groups randomly: sham, CCI, and HBO groups. …
AbstractBackground: Hyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during astrocyte activation and inflammation in a rodent model of neuropathic pain.Methods: Rats were assigned into sham operation, chronic constriction injury (CCI), and CCI + …
AbstractPurpose: Hyperbaric oxygen (HBO) therapy has been suggested to palliate neuropathic pain, but the mechanisms involvedare not well understood. This study explored the involvement of microglial mitophagy via HBO relative to neuropathic paintherapy.Materials and methods: A total of 80 male Sprague Dawley rats were randomly divided into two groups: a normal group(n ¼ 40) and …
Effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia Read More »
