We hypothesized that tissue hyperoxia would enhance and hypoxia inhibit neovascularization in a wound model. Therefore, we used female Swiss-Webster mice to examine the influence of differential oxygen treat-ment on angiogenesis. One milliliter plugs of Matrigels, a mixture of matrix proteins that supports but does not itself elicit angiogenesis, were injected subcutaneously into the mice. …
Hyperoxia and angiogenesis Read More »
Hypothesis: Hyperbaric oxygen (HBO) therapy increases vascular endothelial growth factor (VEGF) levels in wounds.Design: Wounds were monitored for oxygen delivery during HBO treatment, and wound fluids were analyzed for VEGF and lactate on days 2, 5, and 10 following wounding. Setting: Experimental animal model. Interventions: Rats were randomized to HBO therapy and control groups. The …
Effect of Hyperoxia on Vascular Endothelial Growth Factor Levels in a Wound Model Read More »
Hyperbaric oxygen therapy has been approved for primary or adjunctive care in 14 indications.A hyperbaric environment exists when a patient’s whole body is physically exposed to 100%oxygen and pressure that is greater than one atmosphere absolute. Hyperbaric oxygen therapy works through the ideal gas laws and is effective as an adjunctive therapy in the treatment …
The Role of Hyperbaric Oxygen Therapy in Crush Injuries Read More »
Abstract: Background and objectives: Complex limb wounds with multiple tissue involvement are commonly due to high energy trauma. Tissue damage is a dynamic entity and the exact extent of the injury is rarely instantly perceptible. Hence, reconstruction frequently involves a multi-stage procedure concluding with tissue replacement. Materials and Methods: A retrospective study was conducted between …
AbstractMutilated hand injuries are a profound challenge to the plastic surgeon, and suchinjuries often lead to limb loss and severe functional impairment. Hyperbaric oxygentherapy (HBOT) appears to counteract tissue hypoxia and stimulate acute woundhealing. This study was performed to evaluate the efficacy of HBOT as an adjunctivetherapy in patients with a mutilated hand injury. Between …
Is hyperbaric oxygen therapy indispensable for saving mutilated hand injuries Read More »
Hyperbaric oxygen (HBO) therapy has been used as an adjunctive therapy for diabetic foot ulcers, although its mechanism of action is not completely understood. Recently, it has been shown that HBO mobilizes the endothelial progenitor cells (EPCs) from bone marrow that eventually will aggregate in the wound. However, the gathering of the EPCs in diabetic …
Background:This paper outlines therapeutic mechanisms of hyperbaric oxygen therapy (HBO2) and reviews data on its efficacy for clinical problems seen by plastic and reconstructive surgeons.Methods: The information in this review was obtained from the peer-reviewed medical literature.Results: Principal mechanisms of HBO2 are based on intracellular generation of reactive species of oxygen and nitrogen. Reactive species …
Hyperbaric oxygen – its mechanisms and efficacy Read More »
AbstractBackground: Radiation therapy is performed as an adjuvant therapy when indicated following surgical resectionof malignant tumors. However, radiation exposure induces acute or chronic dermatitis, depending on theradiation dose, interval, tissue volume, or irradiated area of the body. Radiation-induced skin ulcers andosteomyelitis of the underlying bone are intractable late-stage complications of radiation therapy, and oftenrequire reconstructive …
THERAPEUTIC MECHANISMS OF action for hyperbaric oxygen(HBO2) are based on elevation of both the partial pressure ofoxygen and hydrostatic pressure. Elevating the hydrostaticpressure increases partial pressure of gases and causes a reductionin the volume of gas-filled spaces according to Boyle’slaw. These actions have direct relevance to treating pathologicalconditions in which gas bubbles are present in …
Oxidative stress is fundamental to hyperbaric oxygen therapy Read More »
Contact electrical burns are more severe than others forms of contact burn injury. We present a 2- year old case of electric injury admitted 48 h after injury treated with Hyperbaric Oxygen Therapy (HBOT) at 1.45 ATA 100%O2 like adjuvant therapy. She had thumb necrosis of right hand with 0.2% burn (0.1% type AB and …
Hyperbaric oxygen therapy for a pediatric electrical burn: A case report Read More »
