Document Category: Toxicology

Increased Efficacy of Antivenom Combined with Hyperbaric Oxygen on Deinagkistrodon acutus Envenomation in Adult Rats

Background: Snakebites are a neglected threat to global human health with a high morbidity rate. The present study explored the efficacy of antivenom with hyperbaric oxygen (HBO) intervention on snakebites, which could provide the experimental basis for clinical adjuvant therapy.Methods: Male Sprague–Dawley rats (n = 96) were randomized into four groups: the poison model was …

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HBO2 in snake envenomation (atrox albinus rattlesnake): a case report in a human

A patient suffered from an envenomation that, at his hospitalization, was judged severe: Grade 3 out of 3, as defined in clinical studies for CroFab™ antidote [Crotalidae Polyvalent Immune Fab (Ovine)]. In addition to the usual antivenom treatment we applied adjunctive hyperbaric oxygen (HBO2) therapy. Our aim was to facilitate better control of the lesions, already presenting as problematic wounds and …

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A Multidisciplinary Approach with Hyperbaric Oxygen Therapy Improve Outcome in Snake Bite Injuries

ABSTRACTAim: Snakebite injuries are common in tropical India among those who are involved in outdoor activities. These injuries results in cellulitis, gangrene at the bite area, bleeding manifestations, compartment syndrome, regional lymphadenopathy, septicemia, hypotension, and disseminated intravascular coagulation (DIC) resulting in significant morbidity and mortality. The purpose of this study is to share our experience of …

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Hyperbaric oxygen therapy after Bothrops lanceolatus snake bites in Martinique: A brief report

AbstractEvery year 10 to 20 cases of snake bites are reported on the Caribbean island of Martinique. The only snake involved, Bothrops lanceolatus, is endemic on the island, and its bite may lead to systemic multifocal thrombotic complications in the absence of the monospecific antivenom. Between January 1988 and January 2009, more than 250 snake bites have been …

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A loxoscelism case received therapeutic apheresis and hyperbaric oxygen therapy

Loxosceles reclusa (L.reclusa) is known to bite humans, and its venom includes several enzymes that cause clinical symptoms. Loxoscelism, a condition due to being bitten by Loxosceles spiders, commonly known as recluses, can involve a range of clinical conditions, from local cutaneous lesions to severe systemic involvement. The diagnosis of loxoscelism is usually made by anamnesis and clinical findings. Magnetic resonance imaging is …

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Nonhealing Wounds Caused by Brown Spider Bites: Application of Hyperbaric Oxygen Therapy

ABSTRACTBACKGROUND: Bites by Loxosceles spiders (also known asrecluse spiders or brown spiders) can cause necrotic ulcerationsof various sizes and dimensions. The current standard of carefor brown spider bites includes analgesics, ice, compression,elevation, antihistamines, and surgical debridement. Hyperbaricoxygen therapy (HBOT) in the treatment of brown spider biteshas been administered in the early stage of ulceration, or …

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Brown Recluse Spider Envenomation: A Prospective Trial Hyperbaric Oxygen Therapy

Objectives: Loxosceles reclusa (brown recluse) spider bites can produce severe skin lesions that may neces sitate extensive surgical repair. This study delineated the effects of hyperbaric oxygen (HBO) therapy on these lesions by performing a prospective controlled animal study. Methods: After approval by the Institutional Animal Care and Use Committee, 41 New Zealand white rabbits received 64 intradermal …

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Comparison of Hyperbaric Oxygen and Dapsone Therapy for Loxosceles Envenomation

 Objective: To determine whether hyperbaric 0, (HBO), dapsone, or HBO plus dapsone affects lesion size in a swine model of Loxosceles envenomation. Methods: In a randomized controlled animal laboratory experiment, 32 piglets were assigned to 1 of 4 equal groups. Each piglet received 15 p,L of purified venom intradermally on day zero. Group 1 received no treatment; group 2 …

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HYPERBARKC OXYGEN EFFECTS ON BROWN RECLUSE SPIDER (LOXOSCELES RECLUSA) ENVENOMATION IN RABBITS

Hyperbaric oxygen effects on brown recluse spider (Loxosceles recluse) envenomation in rabbits. Toxicon 29, 989-996, 1991 .-Human loxoscelism was modeled in albino rabbits by injection of brown recluse spider (Loxosceles recluse) venom, and the effects of daily or twice-daily hyperbarkc oxygen treatment on wound healing were investigated . Lesions similar to those seen in humans …

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Hyperbaric Oxygen Attenuates Withdrawal Symptoms by Regulating Monoaminergic Neurotransmitters and NO Signaling Pathway at Nucleus Accumbens in Morphine-Dependent Rats

AbstractIn this study, we examined whether hyperbaric oxygen (HBO2) plays a detoxification role in withdrawal symptoms in a morphine-dependent rat model. The model was established through injections of morphine at increasing doses for 7 days. Withdrawal symptoms were induced by naloxone injection on the 8th day. The detoxification effect of HBO2 was evaluated using the withdrawal symptom scores, …

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