Document Category: Wounds

Effects of hyperbaric oxygen on gene expressions of procollagen, matrix metalloproteinase and tissue inhibitor of metalloproteinase in injured medial collateral ligament and anterior cruciate ligament

Animal experiments were performed to investigate whether and how the administration of hyperbaric oxygen (HBO) affects gene expressions ofprocollagens, matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in injured medial collateral ligament (MCL) and anterior cruciate ligament (ACL). In 64 Sprague-Dawley rats,the MCL of the left knee was lacerated at the midsubstance, and the …

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Early hyperbaric oxygen therapy improves survival in a model of severe sepsi

Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH,Bickler SW, Perdrizet GA, De Maio A. Early hyperbaric oxygentherapy improves survival in a model of severe sepsis. Am J PhysiolRegul Integr Comp Physiol 317: R160 –R168, 2019. First publishedMay 15, 2019; doi:10.1152/ajpregu.00083.2019.—Sepsis is a majorclinical challenge, with therapy limited to supportive interventions. There fore, the …

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Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy

We present a case of rhino-orbitary mucormycosis which progressed despite liposomal amphotericin and early surgical debridement. Combined echinocandin and high dose liposomal amphotericin, repeated debridement, prolonged therapy with hyperbaric oxygen and continued therapy with posaconazole, along with strict diabetic control, allowed cure without disfigurement.

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Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample

Abstract Purpose: Necrotising soft tissue infection (NSTI) is a deadly disease associated with a sig nificant risk of mortality and long term disability from limb and tissue loss. The aim of this study was to determine the effect of hyperbaric oxygen (HBO2) therapy on mortality, complication rate, discharge status/ location, hospital length of stay and …

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Not Just Full of Hot Air: Hyperbaric Oxygen Therapy Increases Survival in Cases of Necrotizing Soft Tissue Infections

AbstractBackground: The utility of hyperbaric oxygen therapy (HBOT) in the treatment of necrotizing soft tissue in fections (NSTIs) has not been proved. Previous studies have been subject to substantial selection bias becauseHBOT is not available universally at all medical centers, and there is often considerable delay associated with itsinitiation. We examined the utility of HBOT …

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Hyperbaric oxygen therapy as an adjuvant to source control in necrotizing soft tissue infections

Introduction: Necrotizing soft tissue infections (NSTI) are rare but potentially lethal disorders, and adequate management is time- and resource-demanding. This study aims to assess whether variations in the treatment modalities – surgery, hyper baric oxygen (HBO2)therapy and negative pressure wound therapy – had an impact on the length to definitive source control in NSTI patients …

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Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells

Hyperbaric oxygen has proven to be a useful treatment for chronic wounds. However, therapeutic conditions vary between treatment centers, and we wished to investigate the effects of different treatment pressures on cells under inflammatory conditions. Endothelial cells were exposed to a chronic wound model com prising hypoxia (2% O2 at 1 atmosphere absolute (atm abs); PO2 …

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Correction of Hypoxia, a Critical Element for Wound Bed Preparation Guidelines: TIMEO2 Principle of Wound Bed Preparation

Abstract Wound bed preparation is an organized approach to create an optimal environment for wound healing by the use of the most cost-effective therapeutic options. It has become an essential part of wound management and seeks to use the latest findings from molecular and cellular research to maximize the benefits of today’s advanced wound care …

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The Role of Hyperbaric Oxygen Therapy in Enhancing the Rate of Wound Healing with a Focus on Axon Regeneration

Wounds have always afflicted humanity causing pain, suffering and death, and for thousands of years humans have tested and developed various techniques for their ability to induce wound healing. Hyperbaric oxygen therapy (HBOT) refers to placing a patient or their extremity in a chamber in which the pressure is raised several fold above ambient air pressure and the ambient …

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