Document Category: Wounds

Background: Oxygen is vital for healing wounds. It is intricately involved innumerous biological processes including cell proliferation, angiogenesis, andprotein synthesis, which are required for restoration of tissue function andintegrity. Adequate wound tissue oxygenation can trigger healing responsesand favorably influence the outcomes of other treatment modalities.The Problem: Chronic ischemic wounds fail to heal appropriately secondary toextreme …

Oxygen: Implications for Wound Healing Read More »

AbstractBackground—Hyperbaric oxygen (HBO) has been suggested to be beneficial ininflammatory bowel disease but the mechanisms responsible for its therapeu tic eVects have not been elucidated.Aim—To assess the eVect of HBO treat ment on colonic damage in two models ofexperimental colitis, and to examine whether this eVect is mediated by modula tion of NO synthesis.Methods—Colitis was …

Hyperbaric oxygen: a novel modality to ameliorate experimental colitis Read More »

BackgroundHyperbaric oxygen therapy (HBOT) provides 100% oxygen under pressure,which increases tissue oxygen levels, relieves hypoxia and alters inflamma tory pathways. Although there is experience using HBOT in Crohn’s dis ease and ulcerative colitis, the safety and overall efficacy of HBOT ininflammatory bowel disease (IBD) is unknown.AimTo quantify the safety and efficacy of HBOT for Crohn’s …

Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease Read More »

Perineal lesions are a frequent and troublesome com plication of Crohn’s disease. Although there are various surgical and medical therapeutic regimens available totreat these lesions, all have significant associated mor bidity, mortality, and toxicity. Recently, the beneficial effects of hyperbaric oxygen therapy (HBOT) have been described in patients with severe or refractory perineal disease, but …

Hyperbaric Oxygen Therapy for Perineal Crohn’s Disease Read More »

ABSTRACTPURPOSE: Evaluate the application of Hyperbaric Oxygen Therapy (HBO) in patients with Crohn’s disease (CD) refractory topharmacologic therapy, who developed abdominal, anorectal or skin complications.METHODS: Fourteen selected patients with refractory CD and treated at the School of Medicine of Ribeirao Preto, University of SaoPaulo (FMRP-USP) and at the Center of Hyperbaric Medicine, São Paulo Hospital …

Crohn’s disease and hyperbaric oxygen therapy1 Read More »