Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis

AbstractOsteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer. Presently,hyperbaric oxygen therapy (HBOT) is proposed to have a role in improving wound healing in ORN patients. Thereis no strong scientific evidence to confirm the benefits of HBOT for treatment of ORN as an adjunctive treatment.This study aimed to determine the benefits of adjunctive treatment of HBOT in ORN. A retrospective study wasconducted at the Srinagarind Hospital, the Faculty of Medicine, Khon Kaen University, Thailand, between 2011and 2017. The patients diagnosed with ORN, who received adjunctive HBOT before the operation, were enrolled.Complete healing of wounds was the primary outcome. There were 84 ORN patients with a mean age of 58.78years; 54.76% were male and 45.24% were female. HBOT had a role significant in improving wound healing ofORN patients with stages 1 and 2. Poisson regression analysis showed that stage 3 of ORN negatively correlatedwith the number of HBOT dives ( p = 0.001, incidence rates ratio = 0.85). In conclusion, HBOT improved woundhealing of ORN patients with stages 1 and 2. In addition, stage 2 of ORN patients significantly required the high est number of HBOT dives compared to other types of ORN to promote wound healing, whereas stage 3 pa tients, who underwent bone debridement combined with HBOT, initiated to success of treatment processand required a smaller number of dives.