Hyperbaric Oxygen Therapy for Radiation Cystitis in Patients with Prostate Cancer: A Long-Term Follow-Up Study

Abstract Objective: To assess the safety and efficacy of hyperbaric oxygen (HBO) for treating radiation cystitis a long-term fol low-up study was done in patients with prostate cancer, the second most common malignancy in Japan. Patients and Methods: A total of 38 patients at an age of 68 8 8 years with radiation cystitis following irradiation of prostate cancer were treated with HBO at 2 absolute atmospheric pressures for 90 min daily. The average number of HBO treatment ses sions in each patient was 62 8 12. The follow-up period was 11.6 8 3.7 years. We evaluated objective and subjective symptoms periodically with special reference to the initia tion timing of HBO therapy. Results: High efficacy ratios of objective and subjective findings were obtained at 2 and 4 (79–95%) years, respectively. After 7 years’ follow-up, these ratios decreased slightly (72–83%) but still remained stable thereafter (75–88%) without any serious accident. Compari son of late morbidity scores before and 11.6 years after HBO therapy showed significant improvement (p ! 0.0005). Twenty-eight patients (74%) obtained nonrecurrent out come. They had received 18% lower (p ! 0.001) radiation dos age than recurrent patients. The interval between the onset of hematuria and start of HBO treatment in nonrecurrent pa tients was 30% shorter (p ! 0.001) than that of recurrent pa tients. Conclusions: We elucidated the long-term safety and beneficial effect of HBO therapy of radiation cystitis in pa tients with prostate cancer. Early application of HBO treat ment after the onset of hematuria appears to produce favor able outcome. 

Categories: Oncology, Urology