Document Category: Oncology

Background: Hypoxia is associated with increased resistance to chemo- and radiation-therapy.Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and this has been ascribed to enhanced cytotoxicity or neovascularisation. The aim of this study was to elucidate whether hyperoxia also enhances any actual uptake of 5FU (5-fluorouracil) …

Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma Read More »

Abstract. Although hyperbaric oxygen has been shown toenhance the efficacy of radiotherapy and chemotherapyfor the treatment of several malignant tumors, the impactof hyperbaric oxygen on osteosarcoma has not yet beendemonstrated. In this study, we investigated the efficacy ofhyperbaric oxygen alone and in combination with an anti cancer drug as an adjuvant to chemotherapy. In vitro, …

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma Read More »

AbstractTumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report thathyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-benzantraceneinduced mammary rat adenocarcinoma model, and the MET was associated with extensive coordinated gene expressionchanges and less aggressive tumors. One group of tumor bearing rats was exposed to HBO (2 bar, …

Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model Read More »

AbstractWe tested the hypothesis that hyperbaric oxygen (HBO) alone and with chemotherapy (5-FU) attenuates tumor growth ofDMBA-induced tumors in rats. Six series were performed: (1) Controls (air and vehicle 0.9% NaCl i.p.), (2) 5-FU (0.2 mg/kgi.p.), (3) HBO (2 bar for 90 min and vehicle), (4) HBO and 5-FU, (5) HBO (11 days) and air …

Hyperbaric oxygen alone or combined with 5-FU attenuates growth of DMBA-induced rat mammary tumors Read More »

Objectives: The objectives of the study were to test the hypothesis that hyperbaric levels of oxygen enhance the sensitivity of a sarcoma cell line to doxorubicin (Adriamycin) both in vitro and in vivo in a rat model of pulmonary metastases and to test the feasibility of arterialization of mixed venous blood by direct injection of …

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model Read More »

AbstractAbout 5% of cancer patients treated with radiotherapy will have severe late-onset toxicity. Hyperbaric oxygen therapy (HBOT) has been used as a treatment for radiation injuries for decades, with many publications presenting data from small series or individual cases. Moreover, we know that the hypoxic areas of tumours are more resistant to radiation. HBOT increases the oxygen tension …

Hyperbaric oxygen and radiation therapy: a review Read More »

Cancer is a common disease and radiotherapy is one well-established treatment for some solid tumours. Hyperbaric oxygenation therapy(HBOT) may improve the ability of radiotherapy to kill hypoxic cancer cells, so the administration of radiotherapy while breathinghyperbaric oxygen may result in a reduction in mortality and recurrence.ObjectivesTo assess the benefits and harms of administering radiotherapy for …

Hyperbaric oxygenation for tumour sensitisation to radiotherapy Read More »

Background: The importance of tumour hypoxia for the outcome of radiotherapy has been under investi gation for decades. Numerous clinical trials modifying the hypoxic radioresistance in squamous cell car cinoma of the head and neck (HNSCC) have been conducted, but most have been inconclusive, partly dueto a small number of patients in the individual trial. …

Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis Read More »

Background: Hyperbaric oxygen (HBO) therapy is the inhalation of 100% oxygen at a pressure of at least 1.5 atmospheres abso lute (150 kPa). It uses oxygen as a drug by dissolving it in the plasma and delivering it to the tissues independent of hemoglobin. For a variety of organ systems, HBO is known to promote new …

Hyperbaric Oxygen and Radiotherapy Read More »

BackgroundTumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy andmetastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment(HBOT), attenuates tumor growth and shifts the phenotype from mesenchymal to epithelial(MET) in the DMBA-induced mammary tumor model. This study describes the effect ofHBOT on tumor growth, angiogenesis, chemotherapy efficacy and metastasis in a …

Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts Read More »