Background: Our previous study suggested that HBO treatment attenuated neuropathic pain by inhibiting mTOR to induce autophagy in SNL neuropathic pain model. The aim of this study was to evaluate the role of AKT/TSC2/mTOR pathway in SNL and autophagy and determine whetherHBO treatment could relieve neuropathic pain via modulating AKT/TSC2/mTOR pathway. Materials and methods: Rats …
Purpose: Hyperbaric oxygen (HBO) therapy has been suggested to palliate neuropathic pain, but the mechanisms involvedare not well understood. This study explored the involvement of microglial mitophagy via HBO relative to neuropathic paintherapy.Materials and methods: A total of 80 male Sprague Dawley rats were randomly divided into two groups: a normal group(n 1⁄4 40) and …
Effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia Read More »
The present study examined the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen (HBO) preconditioning is triggered by an initial oxidative stress and is associated with an increase of antioxidant enzyme activities as one effector of the neuroprotection. New Zealand White rabbits were subjected to HBO preconditioning, hyperbaric air (HBA) preconditioning, or sham …
Background: The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. Material/Methods: A rat model of TBI was constructed using the modified Feeney’s free-fall method, and 60 SD rats were random-ly divided into three groups – the sham group, …
Background/Aims: Previous studies have proved that the activation of TLR4/NF-κ B signaling pathway is involved in inflammatory processes in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Hyperbaric oxygen (HBO) intervention has successfully been used to treat several animal models of tissue injury via its anti-inflammation property. This study was undertaken to investigate the influence …
Background—Hyperbaric oxygen (HBO) decreases ischemia-reperfusion (IR) induced neutrophil-ICAM adhesion by blocking CD18 polarization. The purpose of this study was to evaluate whether this HBO effect is nitric oxide (NO) dependent and to determine if NO synthase (NOS) is required. Methods—A gracilis muscle flap was raised in 9 groups of male Wistar rats. Global ischemic injury …
Introduction: Ischemia/reperfusion (I/R) injury, such as myocardial infarction, stroke, and peripheral vascular disease, has been recognized as the most frequent causes of devastating disorders and death currently. Protective effect of various preconditioning stimuli, including hyperbaric oxygen (HBO), has been proposed in the management of I/R. Methods: In this study, we searched and reviewed up-to-date published …
Abstract: Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation inrats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effectsof HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley(SD) rats were randomly assigned to the following six groups (n = 6 per group): (1) sham burnwith sham HBO treatment; …
Objectives: Hyperbaric oxygen therapy (HBO) has been used as an adjunctive therapy in the treatment of radiotherapy or bisphosphonate-induced osteonecrosis of the jaw however the effect of HBO on osteoblast formation and mineralisation has not been extensively studied.The current study therefore examined the effects of HBO, elevated pressure or elevated oxygen alone on osteoblast differentiation …
Early stages of avascular necrosis of the femoral head (AVNFH) can be conservatively treated with hyperbaric oxygen therapy (HBOT). This study investigated how HBOT modulates inflammatory markers and reactiveoxygen species (ROS) in patients with AVNFH. Twenty-three male patients were treated with two cycles of HBOT, 30 sessions each with a 30 days break between cycles. …
