Document Category: Toxicology

Hyperbaric oxygen (HBO2) therapy reportedly reduces opiate withdrawal in human subjects. The purpose of this research was to determine whether HBO2 treatment could suppress physical signs of withdrawal in opiate-dependent mice. Male NIH Swiss mice were injected s.c. with morphine sulfate twice a day for 4 days, the daily dose gradually increasing from 50 mg/kg on …

Hyperbaric oxygen treatment suppresses withdrawal signs in morphine-dependent mice Read More »

Methemoglobinemia usually results from exposure to oxidizing substances such as nitrates or nitrites. Iron within hemoglobin is oxidized from the ferrous (Fe2+) state to the ferric (Fe3+)state, resulting in the inability to transport oxygen and carbon dioxide. Clinically, this condition causes functional cyanosis. As methemoglobin levels increase, patients show evidence of cellularhypoxia in all tissues. …

Hyperbaric Oxygenation in the Treatment of Life-Threatening Isobutyl Nitrite-Induced Methemoglobinemia—A Case Report Read More »

Methemoglobinemia is a rare but clinically important condition that should be considered among dif ferential diagnosis’ in cyanosis. The conventional treatments of methemoglobinemia are high flow ox ygen and methylene blue therapies.We present a 52-year-old male patient who admitted to emergency room with severe cyanosis and dyspnea after he was exposed to paint thinner and …

Methemoglobinemia treated with hyperbaric oxygen therapy: A case report Read More »

Abstract—Background: Methylene blue is the first line therapy for methemoglobinemia, but it can be intermittently unavailable due to production issues.For this clinical scenario, alternative treatment options need to be explored. Hyperbaric oxygenation (HBO) is conventionally applied as an adjunctive therapy during the systemic administration of methylene blue.Currently, little is known regarding the effects of HBO …

A CASE OF METHEMOGLOBINEMIA SUCCESSFULLY TREATED WITH HYPERBARIC OXYGENATION MONOTHERAPY Read More »

Hydrogen sulfide is a toxic gas produced as a byproduct of organic waste and many industrial processes. Hydrogen sulfide exposure symptoms may vary from mild (dizziness, headaches, nausea) to severe lactic acidosis via its inhibition of oxidative phosphorylation, leading to cardiac arrhythmias and death. Treatment is generally supportive. We report the case of a patient …

Utilization of Hyperbaric Oxygen Therapy and Induced Hypothermia After Hydrogen Sulfide Exposure Read More »

Objective. To study myocardial and lung injuries initiated by hydrogen sulfide, and evaluate the role and effectiveness of normobaric and hyperbaric oxygen (HBO) treatment in rats. Methods. One hundred healthy male Wistar rats were randomly divided into five groups: A: Normal control group (no H2S); B: H2S-exposed group; C: H2Sþ33% oxygen treatment group; D: H2Sþ50% …

Myocardial and lung injuries induced by hydrogen sulfide and the effectiveness of oxygen therapy in rats Read More »

AbstractCarbon monoxide (CO) is a small molecule poison released as a product of incomplete combustion. CO binds hemoglobin, reducing oxygen delivery. This effect is exacerbated in the burned pregnant patient by fetal hemoglobin that binds carbon monoxide 2.5–3 fold stronger than maternal hemoglobin. With no signature clinical symptom, diagnosis depends on patient injury history, elevated …

Carbon monoxide and cyanide poisoning in the burned pregnant patient: an indication for hyperbaric oxygen therapy Read More »

ABSTRACTCyanide (CN) intoxication inhibits cellular oxidative metabolism and may result in brain damage. Hydroxyco balamin (OHCob) is one among other antidotes that may be used following intoxication with CN. Hyperbaric oxygen (HBO2) is recommended when supportive measures or antidotes fail. However, the effect of hydroxyco balamin or HBO2 on brain lactate and glucose concentrations during …

Hyperbaric oxygen therapy or hydroxycobalamin attenuates surges in brain interstitial lactate and glucose; and hyperbaric oxygen improves respiratory status in cyanide-intoxicated rats Read More »

Patients with acute thermal burns often have pul monary injuries secondary to the inhalation of super heated gases and toxins. For victims trapped in closed spaces, the likelihood of such injuries is increased. In halation of steam causes edema and closure of the upper airway, while inhalation of smoke and hot, dry gas injures the …

Hyperbaric oxygen therapy for acute smoke inhalation injuries Read More »

Abstract-Five patients with smoke inhala tion from house fires presented to the hospital in a comatose state. Carboxyhemoglobin levels were elevated in all five patients, mean = 32% f 6. Arterial blood gases revealed the following means: pH 7.16 &O&i; PC& 35 mm HG f 10.5; HCOJ 12.6 mEq/L kO.07; base excess – 16 mEq/L f …

TREATMENT OF SMOKE INHALATION BY HYPERBARIC OXYGEN Read More »