Document Category: Wounds

Oxidative stress is fundamental to hyperbaric oxygen therapy

THERAPEUTIC MECHANISMS OF action for hyperbaric oxygen(HBO2) are based on elevation of both the partial pressure ofoxygen and hydrostatic pressure. Elevating the hydrostaticpressure increases partial pressure of gases and causes a reductionin the volume of gas-filled spaces according to Boyle’slaw. These actions have direct relevance to treating pathologicalconditions in which gas bubbles are present in …

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Hyperbaric Oxygen Therapy for the Compromised Graft or Flap

Significance: Tissue grafts and flaps are used to reconstruct wounds fromtrauma, chronic disease, tumor extirpation, burns, and infection. Despitecareful surgical planning and execution, reconstructive failure can occur dueto poor wound beds, radiation, random flap necrosis, vascular insufficiency, orischemia–reperfusion (IR). Traumatic avulsions and amputated compositetissues—compromised tissue—may fail from crush injury and excessivelylarge sizes. While never intended, …

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Hyperbaric oxygen therapy for chronic wounds (Review)

BackgroundChronic wounds are common and present a health problem with significant effect on quality of life. Various pathologies may causetissue breakdown, including poor blood supply resulting in inadequate oxygenation of the wound bed. Hyperbaric oxygen therapy(HBOT) has been suggested to improve oxygen supply to wounds and therefore improve their healing.ObjectivesTo assess the benefits and harms …

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Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers

Aims/hypothesis The randomised, double-blind, placebo controlled Hyperbaric Oxygen Therapy (HBOT) in Diabetic Patients with Chronic Foot Ulcers (HODFU) study showed beneficial effect of HBOT. As this treatment is expensive and time-consuming, being able to select patients for therapy would be very useful. The aim of this study was to evaluate whether circulatory variables could help …

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Systematic Review or Meta-analysis Systematic review and meta-analysis of clinical trials examining the effect of hyperbaric oxygen therapy in people with diabetes-related lower limb ulcers

AbstractAim To examine the efficacy of hyperbaric oxygen therapy in healing diabetes-related lower limb ulcers through a meta-analysis of randomized clinical trials.Methods A literature search was conducted to identify appropriate clinical trials. Inclusion required randomized study design and reporting of the proportion of diabetes-related lower limb ulcers that healed. A meta-analysis was performed to examine …

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Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis

Background: Diabetic foot ulcer (DFU), one of the diabetic complications, brings high burden to diabetic patients. Hyperbaric oxygen therapy (HBOT) has been proven to be an effective clinical method for the treatment of DFU. However, the mechanisms still to be elucidated.Methods: Diabetic foot mice model was established, and treated with hyperbaric oxygen. Haematoxylin & Eosin …

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Efficacy of Hyperbaric Oxygen Therapy in Diabetic Foot Ulcers Based on Wagner Classification

Diabetic foot ulcer is a common chronic complication of diabetes mellitus. In addition to conventional primary ther apy, there are adjuvant therapy methods such as hyperbaric oxygen therapy for the healing of diabetic foot ulcer wounds. The present study aimed to determine the efficacy of hyperbaric oxygen therapy in diabetic foot ulcers based on Wagner …

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Computerized planimetry evaluation of hyperbaric oxygen therapy in the treatment of diabetic foot

AbstractBackground. Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults.Objectives. The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot.Material and methods. The  study included 94 patients, 30 females (32%) …

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Therapeutic Outcome of Hyperbaric Oxygen and Basic Fibroblast Growth Factor on Intractable Skin Ulcer in Legs: Preliminary Report

Background: Beneficial effects of hyperbaric oxygen on ischemic vasculardiseases have been noted. Acceleration of wound healing with basic fibroblast growth factor has also been reported. The authors employed combination therapy of hyperbaric oxygen and basic fibroblast growth factor in patients with skin ulcer in legs refractory to conventional therapy.Methods: Three men and four women were …

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