Document Category: Wounds

Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis

Pyoderma gangrenosum (PG), an ulcerating skin condition, is rare in patients with ulcerative colitis (UC). We report a case of successful treatment of PG in a patient with UC using hyperbaric oxygen therapy (HBOT). The patient had UC that was in re mission following treatment with mesalazine and azathioprine therapy. After visiting an orthopedic clinic, …

Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis Read More »

View

Pioderma gangrenoso refractario: utilidad de la terapia combinada. Enfoque en beneficio de la terapia hiperbárica en su tratamiento

El Pioderma Gangrenoso (PG) es un tipo de dermatosis neutrofílica que tiene un componente idiopático, o puede tener asociación con patologías subyacentes sistémicas. Es el resultado de una respuesta exagerada contra estímulos específicos y no específicos. Su primera línea de terapia son los GC; sin embargo, en algunos pacientes, no se logra control de su patología con éste tratamiento …

Pioderma gangrenoso refractario: utilidad de la terapia combinada. Enfoque en beneficio de la terapia hiperbárica en su tratamiento Read More »

View

Hyperbaric Oxygen, Vasculogenic Stem Cells, and Wound Healing

Significance: Oxidative stress is recognized as playing a role in stem cell mobilization from peripheral sites and also cell function. Recent Advances: This review focuses on the impact of hyperoxia on vasculogenic stem cells and elements of wound healing. Critical Issues: Components of the wound-healing process in which oxidative stress has a positive impact on …

Hyperbaric Oxygen, Vasculogenic Stem Cells, and Wound Healing Read More »

View

Improvement of ulcerative pyoderma gangrenosum with hyperbaric oxygen therapy

Pyoderma gangrenosum (PG) is a rare noninfectious destructive neutrophilic dermatosisof unknown origin affecting the skin and occasionally the subcutaneous fat. In this report, we present the results of intensive hyperbaric oxygen (HBO) therapy in a 62-year-old Greek woman who had been diagnosed with ulcerative PG two years ago, but had been resistant to other therapies.

View

Is there a role for hyperbaric oxygen therapy in the treatment of refractory wounds of rare etiology?

Introduction: Delayed wound healing indicates wounds that have failed to respond to more than 4-6 weeks of comprehensive wound care. Wounds with delayed healing are a major source of morbidity and a major cost to hospital and community healthcare providers. Hyperbaric oxygen therapy (HBOT) is a treatment designed to increase the supply of oxygen to wounds …

Is there a role for hyperbaric oxygen therapy in the treatment of refractory wounds of rare etiology? Read More »

View

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo

We hypothesized that oxidative stress from hyperbaric oxygen (HBO2, 2.8 ATA for 90 min daily) exerts a trophic effect on vasculogenic stem cells. Ina mouse model, circulating stem/progenitor cell (SPC) recruitment and differentiation in subcutaneous Matrigel were stimulated by HBO2 and by a physiological oxidative stressor, lactate. In combination, HBO2 and lactate had additive effects. …

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo Read More »

View

Pyoderma gangrenosum: A report of a rare complication after knee arthroplasty requiring muscle flap cover supplemented by negative pressure therapy and hyperbaric oxygen

Summary Pyoderma gangrenosum (PG) is rare ulcerating skin condition easily confused with wound infection following surgery. We report a complicated case of PG following knee arthro plasty where delayed diagnosis and repeated debridements lead to significant tissue loss.Successful reconstruction was achieved with a muscle flap, but subsequent reactivation ofPG and superadded infection placed both the …

Pyoderma gangrenosum: A report of a rare complication after knee arthroplasty requiring muscle flap cover supplemented by negative pressure therapy and hyperbaric oxygen Read More »

View

Hyperbaric oxygen in the treatment of calciphylaxis: A case series and literature review

Aims: Calcific uraemic arteriolopathy (CUA) or calciphylaxis is most com monly seen in end-stage renal disease and is associated with significantmorbidity and mortality. The aim of this study was to determine whetherhyperbaric oxygen therapy (HBOT) is effective in healing calciphylaxislesions and to determine if there are any patient factors that can predictwound healing and patient …

Hyperbaric oxygen in the treatment of calciphylaxis: A case series and literature review Read More »

View

Hyperoxia and angiogenesis

We hypothesized that tissue hyperoxia would enhance and hypoxia inhibit neovascularization in a wound model. Therefore, we used female Swiss-Webster mice to examine the influence of differential oxygen treat-ment on angiogenesis. One milliliter plugs of Matrigels, a mixture of matrix proteins that supports but does not itself elicit angiogenesis, were injected subcutaneously into the mice. …

Hyperoxia and angiogenesis Read More »

View

The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease

We present the case of a non-dialyzed patient with chronic kidney disease and biopsy-proven calciphylaxis who presented with painful cutaneous ulcers on both legs. The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disor der, and the administration of sodium thiosulfate …

The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease Read More »

View